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Rehabilitation Practice and Science

Translated Title

希樂葆不影響骨骼肌細胞增生、移行及F-actin組成

Abstract

Muscle injury is the most common sport related soft-tissue injury. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for muscle injury treatment. The newest guideline (PEACE and LOVE) from British Journal of Sports Medicine in 2019 emphasized the avoidance of anti-inflammatory modalities in acute phase for the concerning about the negative effect on long-term tissue healing. It has been investigated that NSAIDs impeded cell migration which is crucial role in muscle healing. This study was designed to determine the effects of celecoxib, one of the cyclooxygenase-2 (COX-2) inhibitor on cell proliferation and migration in skeletal muscle cells. MTT assay (3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyltetrazolium bromide) was used to examine cell viability. In vitro wounding healing test, transwell filter migration assay and F-actin staining were adopted to evaluate cell migration and spreading. The results showed that celecoxib had no negative effect on in vitro wounding healing test and cell viability. Besides, celecoxib also did not impact cell migration and cell spreading. Despite the ＂PEACE and LOVE＂ guideline, celecoxib might be the better choice compared to the traditional NSAIDs for some inevitable situation due to their possible less influence on the muscle recovery process.

Language

English

First Page

183

Last Page

192

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