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Rehabilitation Practice and Science

Translated Title

中文口吃患者腦活化之正子造影研究

Abstract

Background/Purpose: Although neuroimage studies on English-speaking stutterers have been reported previously, there was few positron emission tomography (PET) study of brain activation in Chinese- speaking stutterers. The purpose of this study was to investigate brain activation patterns in stutterers who speak Chinese.Each subject was scanned via using a PET scanner with a [18F] deoxyglucose marker. The stutterers group received two separate PET scans, one during solo reading (stuttering condition) and the other during choral reading (fluent condition). The normal speakers had only one scan following solo reading.Significant statistical difference in brain activation between the stutterers during solo reading and normal speakers was observed (p＜0.05). For stutterers during solo reading, PET showed right-lateralized activation in the superior frontal gyrus (Brodmann area or BA 11), middle frontal gyrus (BA 8, 9), inferior frontal gyrus (BA 45-47), postcentral gyrus (BA 1-3, 43), and superior temporal gyrus (BA 22). Comparison between solo reading and choral reading in stutterers disclosed significantly more activation in the bilateral medial frontal gyrus (BA 6, 9-11, 21), bilateral cingulate gyrus (BA 24, 31-33), bilateral parahippocampal gyrus (BA 27, 36), left precentral gyrus (BA 4), left caudate body, and right caudate tail.In conclusion, PET study showed over activation of right brain structure (or under activation of left brain), including the motor cortex and primary auditory cortex, in stutterers who speak Chinese. The findings were similar to those in stutterers who speak English, and may indicate deficit in verbal fluency circuit and lack of normal self-monitoring of speech. ( Tw J Phys Med Rehabil 2012; 40(1): 9 - 17 )

Language

English

First Page

9

Last Page

17

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