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Rehabilitation Practice and Science

Translated Title

靜脈注射雙磷酸鹽類藥物引致全葡萄膜炎：病例報告

Abstract

As human life expectancy has increased, osteoporosis has become a major epidemic disorder. The most common consequences of this are fractures in different parts of the body. In addition to regular follow-up tests of bone-mineral density, treatment methods include: 1. increasing the dietary intake of calcium and vitamin D, 2. maintenance of body weight, avoiding alcohol and tobacco, regular exercise, and fall prevention, 3. medications, the most widely used being bisphosphonates. Bisphosphonates can limit bone loss via the inhibition of osteoclasts. They have been widely prescribed for senile osteoporosis, osteoporosis due to administration of steroids, bone loss due to malignancies with bone metastasis, and hypercalcemia. Though they are widely accepted, there are still some reported adverse effects, such as gastro-intestinal discomfort, hypocalcemia, musculoskeletal pain, and ocular inflammation, though the latter is rarely seen.We report the case of a 60-year-old female with a history of hypercholesteremia and osteopenia, which was noted after a recent general physical examination. She exhibited severe pain in the right eye and deterioration of visual acuity with black and purple shadows, after an intravenous injection of zoledronic acid four days prior. Examination with a slitlamp showed fine keratic precipitations in the cornea of the right eye and numerous cells in the anterior chamber with flares. This led to a diagnosis of acute panuveitis of the right eye. The laboratory examination, including immunological tests, did not reveal other possible causes of panuveitis. Since there were no other possible causes of panuveitis, Zoledronic acid-associated ocular inflammation was diagnosed.

Language

Traditional Chinese

First Page

187

Last Page

193

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