•  
  •  
 

Rehabilitation Practice and Science

Translated Title

生長期大白鼠骨骼對機械負重的適應性 : 組織形態學研究

Abstract

Six-week-old male rats were subjected to right hindlimb immobilization or served as control for 0,4, 6, 8,12, or 24 weeks. There were double-labeled with bone markers prior to sacrifice. The right limb was immobi-lized by sciatic nerve denervation and considered unloaded. Static and dynamic histomorphometry were performed on 20- urn-thick Villanueva stained, undecalcified sections of the proximal tibial metaphysis and thetibial shaft.In the unloaded limb, immobilization induced cancellous and cortical bone loss. Unloading caused a negative trabecular bone balance from a combination of elevated bone resorption and depressed bone formation. The bone loss was accompanied by poorer trabecular architecture(trabacular number decreased and trabecular separation increased).Unloading shut off nearly all periosteal bone formation and accelerated bone marrow expansion. The effects of unloading appeared to be mediated by recruiting fewer osteoblasts which showed inhibitedactivity, these histological changes lowered cortical bone mass by inhibiting diaphyseal cross sectional expansion and enlarging the bone marrow cavity. These findings indicate that the rat skeleton can quickly adapt to mechanical usage. Therefore, the one-legged immobilization model can be useful in studies of the mechanism of structural adaptation to mechanicalusage.

Language

Traditional Chinese

First Page

120

Last Page

131

Download

Share

COinS