Ultrasound-guided regenerative injection for carpal tunnel syndrome: A narrative review and authors' clinical experience

Authors

Yung-Tsan Wu, Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Centers, Taipei, Taiwan
King Hei Stanley Lam, The Hong Kong Institute of Musculoskeletal Medicine, Hong Kong
Chueh-Hung Wu, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Ke-Vin Chang, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Wei-Ting Wu, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Tyng-Guey Wang, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Wen-Shiang Chen, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Chih-Peng Lin, Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Kenneth Dean Reeves, Private Practice PM&R and Pain Management, Roeland Park, KS, USAFollow

Abstract

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy but current conservative treatments are unsatisfactory. Recently, clinical trials using ultrasound-guided regenerative injection with 5% dextrose water or platelet-rich plasma have reported clinically and statistically significant benefits compared to current conservative treatments for the treatment of CTS. Regenerative injection for CTS is increasingly being utilized, proportional to the worldwide expansion of skills in the use of ultrasound guidance for precise injection and localization, and due to accumulating evidence that it enhances the success rate of conservative treatment, and reduces the rate of surgery. In this narrative review, our goals are to introduce ultrasound-guided regenerative injection and current injection methods, to discuss potential mechanisms, to describe results from recent clinical studies, and to provide perspectives from our clinical experience.

Recommended Citation

Wu, Yung-Tsan; Lam, King Hei Stanley; Wu, Chueh-Hung; Chang, Ke-Vin; Wu, Wei-Ting; Wang, Tyng-Guey; Chen, Wen-Shiang; Lin, Chih-Peng; and Reeves, Kenneth Dean (2024) "Ultrasound-guided regenerative injection for carpal tunnel syndrome: A narrative review and authors' clinical experience," Rehabilitation Practice and Science: Vol. 2024: Iss. 2, Article 5.
DOI: https://doi.org/10.6315/3005-3846.2236
Available at: https://rps.researchcommons.org/journal/vol2024/iss2/5