Delayed Localized Hypersensitivity Reactions to an Adenoviral Vector Vaccine—A Literature Review and A Case Report with Serial Ultrasonography Follow-Up

Authors

Chih-Ying Wu, Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi
Chien-Min Chen, Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chiayi
Szu-Han Wang, Department of Emergency, Chang Gung Memorial Hospital, Chiayi
Chia-Hung Lin, Department of Physical Medicine and Rehabilitation, Lin Shin Hospital, Taichung, TaiwanFollow

Abstract

Severe acute respiratory syndrome coronavirus 2 has changed our life worldwide. Vaccination plays an important role in this pandemic to reduce virus transmission and lower the mortality risk. However, as vaccination rates increase, so do the reported adverse effects. This report describes a case of 28-year-old female with severe subcutaneous swelling persisting almost 1 month after receiving the recombinant adenoviral vector vaccine (ChAdOx1 nCov-19, AZD1222), despite paracetamol prophylaxis. The ultrasonography showed a hyperechoic swelling in the subcutaneous layer and a diffuse hypoechoic muscle layer. The phenomenon results from delayed hypersensitivity, however, its clinical picture is often confused with cellulitis and abscess. Ultrasonography is a real-time and convenient diagnostic tool to help clinical practitioners determine the differential diagnoses

Recommended Citation

Wu, Chih-Ying; Chen, Chien-Min; Wang, Szu-Han; and Lin, Chia-Hung (2023) "Delayed Localized Hypersensitivity Reactions to an Adenoviral Vector Vaccine—A Literature Review and A Case Report with Serial Ultrasonography Follow-Up," Rehabilitation Practice and Science: Vol. 2023: Iss. 2, Article 5.
DOI: https://doi.org/10.6315/3005-3846.2222
Available at: https://rps.researchcommons.org/journal/vol2023/iss2/5