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Rehabilitation Practice and Science

Translated Title

生長因子在癒合不良傷口之臨床應用初步報告

Abstract

Growth factor was reported to be effective in promoting wound healing, possibly through the mechanisms of stimulating DNA synthesis, chemotaxis of fibroblasts, embryogenesis, angiogenesis and enhancement of epithelialization. For investigation of the clinical result, 8 cases with poor healing wounds were treated by our own product of ointment with growth factor. They were admitted to Chang Gung Memorial Hospital from Feb. to December 1988. Among them, three were DM foot complicated with peripheral vascular disease and received below- knee amputation, three were sacrum pressure sore, and two were traumatic injury with extensive skin defect. All of these patients had received conventional wound care for a period of time or with skin graft, but resulted in poor wound healing.After the application of growth factor to those wounds, all of them had remarkable improvement, and were healed within 3 weeks to 102 days. There were no any noxious complication such as inflammation, infection, allergy, local irritation, or with any systemic side effect. From this preliminary clinical application study, growth factor is proved to be very effective even in poor healing wounds, suggesting enough benefits to expand to a larger study of further research.

Language

Traditional Chinese

First Page

70

Last Page

74

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