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Rehabilitation Practice and Science

Translated Title

疑似類固醇肌肉病變患者的研究

Abstract

The purpose of this study is to investigate the myopathy induced by steriod therapy with clinical symptoms and signs, the dosage and duration of steriod use, determination of serum muscle enzyme and EMG turns-amplitude analysis. 23 inpatients, aged from 16 to 62 years old. duration of onset from 6 months to 20 years, were studied. Among this 23 patients. 17 were SLE. 3 RA. 1 CGN and 2 cervical syndrome. All had been under steroid medication for a variable period. Electrodiagnostic procedure including NCV of median, ulnar, radial, pcroneal and tibial nerves, EMG with turns-amplitude analysis of BIC, EDC. QUA and TIB muscle were performed. Correlation between clinical symptoms and signs, serum muscle enzyme levels, the dosage .and duration of steroid medication and EMG findings were studied. In 22 out of 23 patients, the NCV were within normal limit. In 19 cases, there were one or more muscles which had myopathic pattern in EMG turns-amplitude analysis. Besides myopathic finding. 15 out of 19 patients had other side effects caused by long-term use of steroid medication- Tile CPK and SGOT levels in 18 patients were within normal range, but there were variable degree of elevation of LDH level. There was no significant correlation between tile severity of myopatllic change and dosage & duration of steroid use. EMG turns-amplitude analysis may be a valuable tool for early detection of steroid induced myopathy.

Language

Traditional Chinese

First Page

71

Last Page

75

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