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Rehabilitation Practice and Science

Translated Title

非類固醇抗炎藥物對肌腱纖維細胞移行、增生及膠原蛋白合成的影響

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy. Tendon healing requires migration of tendon cells to the repair site, followed by proliferation of these cells and collagen synthesis. Purpose: This study evaluated the effects of acetaminophen, etodolac, and indomethacin on tenocyte migration, proliferation, and synthesis of type I and III collagen. Methods: Rat Achilles tendon cells were treated with acetaminophen, etodolac, and indomethacin. Tendon cell migration and proliferation were assessed using transwell filter migration assay and MTT assay, respectively. The expression of collagen I and III mRNA were evaluated by quantitative real-time polymerase chain reaction. Results: Unlike acetaminophen, etodolac and indomethacin significantly reduced tenocyte migration (p ＜ 0.05). No effect of acetaminophen, etodolac, and indomethacin on cell proliferation was observed. The gene expressions of collagen I and III were not affected by acetaminophen, etodolac, or indomethacin treatment. Conclusion: Acetaminophen has no effect on tendon cell migration, proliferation, and type I and III collagen synthesis. Etodolac and indomethacin, similar to other non-selective NSAIDs, inhibit tendon cell migration but have no effect on tendon cell proliferation and type I and III collagen synthesis.

Language

English

First Page

161

Last Page

169

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