Current Regenerative Injection Treatment For Rotator Cuff Disease: A Review Article and Practical Algorithm

Authors

• Abdallah El-Sayed Allam, Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.Follow
• Manal Hassanien, Rheumatology and Rehabilitation Department, Assiut University, Assiut, Egypt
• Ahmed Omar Mahmoud Abdallah, Consultant of Pain Medicine, Department of Anesthesia and Intensive Care, Faculty of Medicine, New Valley University, New Valley, Egypt.

Abstract

Rotator cuff disease is a prevalent musculoskeletal condition affecting shoulder function and quality of life. Traditional management includes conservative treatments and surgery, but ultrasound-guided regenerative orthobiological interventions have emerged as effective alternatives. This review examines epidemiology, risk factors, clinical presentation, and diagnostic approaches to rotator cuff disease, with an emphasis on the role of ultrasound-guided regenerative injections. Specific techniques such as platelet-rich plasma, alpha-2 macroglobulin, lipoaspirate, and bone marrow concentrate are discussed. Recent human studies highlight the efficacy and safety of these interventions, supporting their integration into clinical practice.

Recommended Citation

Allam, Abdallah El-Sayed; Hassanien, Manal; and Abdallah, Ahmed Omar Mahmoud (2026) "Current Regenerative Injection Treatment For Rotator Cuff Disease: A Review Article and Practical Algorithm," Rehabilitation Practice and Science: Vol. 2026: Iss. 2, Article 7.
DOI: https://doi.org/10.6315/3005-3846.2286
Available at: https://rps.researchcommons.org/journal/vol2026/iss2/7